Martin Picard

Oct 7, 2024 | nature.com | Alan Cohen |Martin Picard

AbstractAging involves seemingly paradoxical changes in energy metabolism. Molecular damage accumulation increases cellular energy expenditure, yet whole-body energy expenditure remains stable or decreases with age. We resolve this apparent contradiction by positioning the brain as the mediator and broker in the organismal energy economy.

Nov 29, 2023 | cell.com | Sam Kavoosi |Martin Picard |Brett A. Kaufman

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Apr 26, 2023 | nature.com | José Antonio Enríquez |Martin Picard

AbstractMitochondria have cell-type specific phenotypes, perform dozens of interconnected functions and undergo dynamic and often reversible physiological recalibrations. Given their multifunctional and malleable nature, the frequently used terms ‘mitochondrial function’ and ‘mitochondrial dysfunction’ are misleading misnomers that fail to capture the complexity of mitochondrial biology.