Martina Braun

1 month ago | nature.com | Michael Scherer |Indranil Singh |Martina Braun |Pedro Sanchez |Pedro Sánchez |Dominik Lindenhofer | +13 more

AbstractCurrent approaches used to track stem cell clones through differentiation require genetic engineering1,2 or rely on sparse somatic DNA variants3,4, which limits their wide application. Here we discover that DNA methylation of a subset of CpG sites reflects cellular differentiation, whereas another subset undergoes stochastic epimutations and can serve as digital barcodes of clonal identity.

Dec 2, 2024 | genomebiology.biomedcentral.com | Katherine Kelly |Michael Scherer |Martina Braun |Pavlo Lutsik |Christoph Plass