Mary B Goldring

Oct 31, 2023 | science.org | Michael Z. Miao |Jia Tong Loh |Mary B Goldring |Qian Su

Redox-active endosomes mediate α5β1 integrin signaling and promote chondrocyte matrix metalloproteinase production in osteoarthritisMichael Z. Miao https://orcid.org/0000-0001-6203-2129, Qian Peter Su https://orcid.org/0000-0001-7364-3945, [...] , Yang Cui, Edward M. Bahnson https://orcid.org/0000-0001-8578-0517, [...] , Gang Li https://orcid.org/0000-0003-0759-9063, Menglin Wang https://orcid.org/0000-0002-5348-5983, Yuchen Yang, John A.

Oct 31, 2023 | science.org | Michael Z. Miao |Jia Tong Loh |Mary B Goldring

AbstractFibronectin (FN) fragments stimulate catabolic signaling, and, by binding to integrins, they induce chondrocytes to increase the production of matrix metalloproteinases, including MMP-13. In this issue of Science Signaling, Miao et al. reveal that internalization of a FN fragment, but not intact FN, by α5β1 integrin results in the formation of ROS-producing endosomes (redoxosomes) through which chondrocytes detect and respond to damaged matrix by producing more MMP-13.

Oct 31, 2023 | science.org | Michael Z. Miao |Jia Tong Loh |Mary B Goldring

Editor’s summaryAtopic dermatitis (a type of eczema) is an itchy and painful inflammatory skin disorder of unknown cause, which is associated with decreased function of T cell signaling mediator CARD11 in some patients. Loh et al. found that a scaffolding protein may contribute to CARD11 repression and increased severity of atopic dermatitis symptoms in mice.

Oct 31, 2023 | science.org | Michael Z. Miao |Jia Tong Loh |Mary B Goldring |Leslie K. Ferrarelli

AbstractGlia mediate two-way signaling between the brain and gut that supports sleep and healthy aging. SIGN UP FOR THE SCIENCEADVISER NEWSLETTER The latest news, commentary, and research, free to your inbox daily The gut-brain axis is increasingly recognized as a central regulator of health. Changes in the composition of gut microbiota (called dysbiosis), inflammation in the brain, and sleep fragmentation are associated with a shorter lifespan. Xu et al.

Oct 31, 2023 | sciencemag.org | Michael Z. Miao |Jia Tong Loh |Mary B Goldring

FocusCELL BIOLOGYGet full access to this articleView all available purchase options and get full access to this article. REFERENCES AND NOTES1R. F. Loeser, Integrins and chondrocyte-matrix interactions in articular cartilage. Matrix Biol. 39, 11–16 (2014). 2M. L. Barilla, S. E. Carsons, Fibronectin fragments and their role in inflammatory arthritis. Semin. Arthritis Rheum. 29, 252–265 (2000). 3G. A. Homandberg, C. Wen, F.