Mary B. Makarious

Nov 20, 2024 | nature.com | Elaine Chew |Zheng Li |Michelle Lian |Vincent C. T. Mok |Clement C Tham |Mary B. Makarious | +5 more

AbstractParkinson’s disease (PD) is an incurable, progressive and common movement disorder that is increasing in incidence globally because of population aging. We hypothesized that the landscape of rare, protein-altering variants could provide further insights into disease pathogenesis. Here we performed whole-exome sequencing followed by gene-based tests on 4,298 PD cases and 5,512 controls of Asian ancestry.