Masahiro Nakajima

Jul 18, 2023 | elifesciences.org | Yoshinao Koike |Masahiro Nakajima |Nao Otomo |Masahiko Takahata

Editors’ note: the authors resubmitted a revised version of the paper for consideration. What follows is the authors’ response to the first round of review. We thank you for the comprehensive review of our manuscript and valuable suggestions. We have again discussed the two weaknesses you have pointed out. As for the lack of replication, we added new replication data and evaluated the reproducibility. Our study originally conducted meta-analyses using three datasets.

Mar 28, 2023 | cell.com | Masahiro Nakajima |Joint Diseases |Masaru Koido |Long Guo

Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common intractable disease that causes spinal stenosis and myelopathy. We have previously conducted genome-wide association studies for OPLL and identified 14 significant loci, but their biological implications remain mostly unclear. Here, we examined the 12p11.22 locus and identified a variant in the 5′ UTR of a novel isoform of CCDC91 that was associated with OPLL.