Matheswaran Kandasamy

Oct 4, 2024 | biorxiv.org | Matheswaran Kandasamy |Hana Andrew |Robert Mitchell |Iwan G Raza

AbstractTregs are critical regulators of the immune response, but the cellular signalling pathways that control their development and homeostasis remain to be determined. We found that glycogen synthase kinase-3 (GSK3), a kinase which integrates signals from AKT and mTOR, was essential for Treg development, restraining fatal autoimmunity. Loss of Gsk3 led to metabolic rewiring in Tregs, with disordered nucleotide metabolism and activation of OxPhos.