Mathieu Favier

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The human VGLUT3-pT8I mutation elicits uneven striatal DA signaling, food or drug maladaptive consumption in male mice - Nature Communications

Jul 6, 2024 | nature.com | Mathieu Favier |Elena Garcia |Elena García |Fiona Henderson |Veronique BERNARD |Yulong Li | +5 more

AbstractCholinergic striatal interneurons (ChIs) express the vesicular glutamate transporter 3 (VGLUT3) which allows them to regulate the striatal network with glutamate and acetylcholine (ACh). In addition, VGLUT3-dependent glutamate increases ACh vesicular stores through vesicular synergy. A missense polymorphism, VGLUT3-p.T8I, was identified in patients with substance use disorders (SUDs) and eating disorders (EDs).
The human VGLUT3-pT8I mutation elicits uneven striatal DA signaling, food or drug maladaptive consumption in male mice - Nature Communications

Jul 6, 2024 | nature.com | Mathieu Favier |Elena Garcia |Elena García |Fiona Henderson |Veronique BERNARD |Yulong Li | +5 more

AbstractCholinergic striatal interneurons (ChIs) express the vesicular glutamate transporter 3 (VGLUT3) which allows them to regulate the striatal network with glutamate and acetylcholine (ACh). In addition, VGLUT3-dependent glutamate increases ACh vesicular stores through vesicular synergy. A missense polymorphism, VGLUT3-p.T8I, was identified in patients with substance use disorders (SUDs) and eating disorders (EDs).

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