Matthew A Schaich

Feb 15, 2024 | biorxiv.org | Sarah R. Hengel |Katherine G. Oppenheimer |Chelsea Smith |Matthew A Schaich

AbstractTemplated DNA repair that occurs during homologous recombination and replication stress relies on RAD51. RAD51 activity is positively regulated by BRCA2 and the RAD51 paralogs. The Shu complex is a RAD51 paralog-containing complex consisting of SWSAP1 and SWS1. We demonstrate that SWSAP1-SWS1 binds RAD51, maintains RAD51 filament stability, and enables strand exchange.