Matthew Mosley

1 month ago | biorxiv.org | Franziska Pohl |Brian Egan |Daniel Schneider |Matthew Mosley

AbstractSodium is an essential nutrient, but it can be toxic in excess. In humans, excessive ingestion of dietary sodium is a prevalent cause of high blood pressure, which contributes to age-related diseases including stroke and heart disease. To elucidate how sodium levels influence animal aging, we used C. elegans, a powerful model system to study development and aging. Most experiments on this animal are conducted in standard culture conditions: Nematode Growth Medium (NGM) agar with a lawn of E.

Dec 6, 2024 | onlinelibrary.wiley.com | Matthew Mosley |Holly E Kinser |Nicholas Stroustrup |Tim Schedl

C. elegans Caenorhabditis elegans GFP Green fluorescent protein PCA Principal component analysis RNA-seq RNA sequencing 1 INTRODUCTION A fundamental and open question in the field of gerontology is the source of heterogeneity in lifespan among individuals of the same species. Even in model organisms, in which the variables of genetics and environment can be controlled, the mechanisms underlying the distribution of lifespans within a population remain a mystery.

Oct 7, 2024 | collider.com | Matthew Mosley |Ima Ifum

There are few names more synonymous with hip-hop than Tupac Shakur. He’s one of the best-selling artists in the history of music, and despite generations of rappers rising and falling in the time since his tragic death at the age of just 25, you don’t have to look far to find his influence still guiding the hands of street poets everywhere. However, as difficult as it is to imagine, there was a time when that wasn’t the case.

Sep 14, 2024 | collider.com | Shawn Van Horn |Matthew Mosley

One of the most tragic facts about cinema is that John Carpenter is only being recognized as one of horror’s greatest directors decades after he should have been. While his title as the master of horror is now undisputed, there was a time when his films were largely derided by critics, only being re-evaluated following successful runs on home video and the midnight circuit.

Jan 6, 2024 | collider.com | Matthew Mosley

Heat had a challenging journey to the big screen, but it ultimately became one of the most influential films in the crime genre. The film showcases a large and expansive world of characters, with even the most inconsequential ones receiving their moment in the spotlight. Heat breaks convention by creating a narrative structure that encompasses multiple plotlines, creating a realistic portrayal of the bustling city of Los Angeles. Heat had a long journey to the big screen.