Mattias Mandorfer

Jul 3, 2024 | onlinelibrary.wiley.com | Bernhard Scheiner |Nina Dominik |Mattias Mandorfer

We thank Dr. Kountouras et al. for their interest in our work.1, 2 As outlined in our recent study2 as well as previous work from our group,3 there is little clinical evidence suggesting that levels of coagulation proteins (neither VWF nor the factor VIII/protein C ratio) per se represent disease-driving mechanisms in chronic liver disease. Rather, these factors appear to reflect the natural course of disease as their levels are strongly correlated with liver disease severity.