Matvey Pilagov

Jun 28, 2024 | biorxiv.org | Sonette Steczina |Michael Regnier |Matvey Pilagov |Ateeqa Naim

AbstractCardiac muscle contraction is mediated by myosin binding from the thick filament of the sarcomere to the thin filament in an ATP powered reaction. This process is highly regulated on a beat-to-beat basis by calcium interactions with the thin filament. Additionally, the number of heads available for participation in contraction is also regulated, resulting in a dynamically variable reserve of heads for controlling contractile force.