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Feb 21, 2025 | 
nature.com | Maximilian Merz |David Fandrei |Eva Heger |Viola Schweinsberg |Uwe Platzbecker |Michael Hallek | +3 more
AbstractChimeric antigen receptor (CAR) T cells and bispecific T cell engagers have become integral components in the treatment of relapsed/refractory multiple myeloma. We report a 63-year-old male who received ciltacabtagene autoleucel CAR T cells and the GPRC5D × CD3 bispecific talquetamab for early relapse of his multiple myeloma. Nine months after CAR T therapy, he developed a symptomatic leukemic peripheral T cell lymphoma with cutaneous and intestinal involvement.
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Dec 8, 2024 | 
fnweb.de | Maximilian Merz
Die Merlins Crailsheim haben in der 2. Basketball-Bundesliga „Pro A“ gegen Rasta Vechta II nach zuletzt drei Heimniederlagen verdient mit 95:69 gewonnen. Der erste Durchgang gehörte dabei eindeutig den „Zauberern“, die sich angeführt von Vize-Kapitän Vinnie Shahid über 20 Minuten absetzten. Die Crailsheimer Überlegenheit des ersten Durchgangs setzte sich auch in den zweiten 20 Minuten weiter durch und endete in einem erlösenden Heimsieg.
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Dec 4, 2024 | 
nature.com | Maximilian Merz |Danai Dima |Nausheen Ahmed |Friedrich Stölzel |Fabian Müller |Aina Oliver-Caldes | +12 more
AbstractDespite the astonishing outcomes after chimeric antigen receptor (CAR) T-cell therapy for relapsed refractory multiple myeloma (RRMM), most patients eventually relapse. There are only limited data available on salvage therapies following relapse after BCMA-directed CAR T-cell therapy.
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Dec 4, 2024 | 
nature.com | Sarah Flossdorf |Sandra Sauer |Hartmut Goldschmidt |Monika Engelhardt |Robert Zeiser |Vladan Vucinic | +5 more
AbstractIdentifying patients who may benefit from autologous stem cell transplantation (ASCT) in newly diagnosed multiple myeloma is crucial, especially in the era of effective induction and consolidation strategies. We analyzed data from 12763 patients enrolled in the German Registry for Hematopoietic Stem Cell Transplantation and Cell Therapy (DRST), distinguishing those who underwent single (n = 8736) or tandem ASCT (n = 4027) from 1998 to 2021.
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Dec 4, 2024 | nature.com | Maximilian Merz |Danai Dima |Nausheen Ahmed |Friedrich Stölzel |Fabian Müller |Aina Oliver-Caldes | +12 more
AbstractDespite the astonishing outcomes after chimeric antigen receptor (CAR) T-cell therapy for relapsed refractory multiple myeloma (RRMM), most patients eventually relapse. There are only limited data available on salvage therapies following relapse after BCMA-directed CAR T-cell therapy.
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Aug 26, 2024 | 
nature.com | Maximilian Merz
Early trials of immune checkpoint inhibitors (ICIs) in multiple myeloma (MM) showed increased mortality, halting their development. A study now reports promising results and distinct changes in the immune microenvironment after TIGIT and LAG3 blockade in heavily pre-treated patients with MM, marking a potential revival for ICIs in MM therapy.
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Jul 28, 2024 | 
mdpi.com | Maximilian Merz |Stephan Skornitzke |Simone C. Brandelik |Stefanie Rahn
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Mar 10, 2024 | 
fnweb.de | Maximilian Merz
Crailsheim – Chemnitz 82:97AdUnit Mobile_Pos2AdUnit Content_1Crailsheim: Cook (16), Stuckey (6), Bagette (9), Wulff, Oduro, Bleck (12), Darden (6), Kindzeka (9), Murray-Boyles (14), Westermann (7), Smith (3). Heimspielwochenende für die Merlins: Nach knapp einem Monat ohne Spiel vor heimischer Kulisse wartete in den Niners Chemnitz der Tabellenzweite mit der aktuell besten Abwehr der Liga zum Auftakt in die entscheidende Saisonphase auf die „Zauberer“.
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Oct 1, 2023 | 
fnweb.de | Maximilian Merz
Vor 145 Tage verabschiedeten sich die Merlins in der Basketball Bundesliga am 34. Spieltag der Saison 2022/23 in Weißenfels in die Sommerpause. Am Freitagabend stand er dann endlich wieder vor der Tür – Gameday in der „Arena Hohenlohe“ in der Liga der Weltmeister. AdUnit Mobile_Pos2AdUnit Content_1Die Merlins Crailsheim empfingen zum Auftakt der neuen BBL-Saison die Überraschungsmannschaft der abgelaufenen Saison aus Rostock.
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Jul 25, 2023 | 
frontiersin.org | Sandy Wong |Arne Östman |Patrizia Leone |Maximilian Merz
1University of California San Francisco (UCSF) Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, United States 2Genentech Inc., South San Francisco, CA, United States 3O’Neal Comprehensive Cancer Center, The University of Alabama at Birmingham, Birmingham, AL, United States 4Tisch Cancer Institute, Icahn School of Medicine at Mt. Sinai, New York, NY, United States 5Yale School of Medicine, New Haven, CT, United States 6Division of Oncology,...
