Meg Byron

Jan 9, 2024 | biorxiv.org | Lisa Hall |Meg Byron |Jeanne Lawrence |Kevin M Creamer

AbstractThe linear DNA sequence of mammalian chromosomes is organized in large blocks of DNA with similar sequence properties, producing a pattern of dark and light staining bands on mitotic chromosomes. Cytogenetic banding is essentially invariant between people and cell-types and thus may be assumed unrelated to genome regulation. We investigate whether large blocks of Alu-rich R-bands and L1-rich G-bands provide a framework upon which functional genome architecture is built.