Megan J. Roy-Puckelwartz

Jul 31, 2023 | frontiersin.org | Yiqun Wu |Andreas Brodehl |Megan J. Roy-Puckelwartz

1. Introduction HCM is the most common inherited cardiac disease affecting at least 1:500 of the general population (1). In adult probands, HCM is defined as the thickening of the left ventricle (LV) wall ≥ (13) 15 mm in the absence of obvious causes for the observed magnitude of hypertrophy (2); this definition includes both familial and sporadic forms of the disease. HCM is characterized by high clinical heterogeneity. Many patients are asymptomatic and early diagnosis is difficult.