Megan Noonan

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Identification of human pathways acting on nuclear non-coding RNAs using the Mirror forward genetic approach - Nature Communications

1 month ago | nature.com | Rui che |Megan Noonan |Hong Qun Luo

AbstractDespite critical roles in diseases, human pathways acting on strictly nuclear non-coding RNAs have been refractory to forward genetics. To enable their forward genetic discovery, we developed a single-cell approach that “Mirrors” activities of nuclear pathways with cytoplasmic fluorescence.

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