Mehdi Pirooznia

Nov 9, 2023 | frontiersin.org | Mehdi Pirooznia |Lin Wu |Ming Yi

1 IntroductionThe widespread application of immune-checkpoint inhibitors (ICIs) in the treatment of non-small-cell lung cancer (NSCLC) has substantially prolonged patients’ overall survival (1). However, they are not always effective for the entire population.

Jul 27, 2023 | frontiersin.org | Mehdi Pirooznia |Aimin Jiang |Xiaoling Zhang

1 IntroductionProtein phosphorylation, which was first discovered in 1955, is one of the most important post-transcriptional modifications. It plays very important roles in regulating cell cycle, growth, proliferation, differentiation and other cell activities (1). Abnormal protein phosphorylation is one of the hallmarks of cancer cells and, in many cases, is a prerequisite for maintaining tumor development and progression.