Melanie Hinkel

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Co-targeting SOS1 enhances the antitumor effects of KRASG12C inhibitors by addressing intrinsic and acquired resistance - Nature Cancer

Aug 5, 2024 | nature.com | Venu Thatikonda |Kaja Kostyrko |Donát Alpár |Daniel Gerlach |Melanie Hinkel |Jessica M Molkentine | +5 more

AbstractCombination approaches are needed to strengthen and extend the clinical response to KRASG12C inhibitors (KRASG12Ci). Here, we assessed the antitumor responses of KRASG12C mutant lung and colorectal cancer models to combination treatment with a SOS1 inhibitor (SOS1i), BI-3406, plus the KRASG12C inhibitor, adagrasib.

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