Melita A Gordon

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Clofazimine pharmacokinetics in HIV‐infected adults with diarrhea: Implications of diarrheal disease on absorption of orally administered therapeutics

Jan 2, 2024 | ascpt.onlinelibrary.wiley.com | cindy zhang |Thomas Conrad |David Hermann |Melita A Gordon

WHAT IS THE CURRENT KNOWLEDGE ON THE TOPIC? Although clofazimine's pharmacokinetic and safety profiles have been studied in healthy volunteers, leprosy patients, and multi-drug-resistant tuberculosis patients, no study has been conducted for patients with diarrhea-related symptoms, and it is unclear whether diarrhea should be considered when dosing clofazimine for cryptosporidiosis. WHAT QUESTION DID THIS STUDY ADDRESS?

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