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Jul 11, 2024 | 
science.org | Jacob Landis |Meng-Ju Wu
AMSBIO launches spatial biology multi-omics profiling serviceNanoString GeoMx DSP is a new flexible multi-omics platform that enables reliable quantitative assessment of the spatial heterogeneity within various sample types, including FFPE, TMAs, and fresh-frozen tissue—with no prequalification required.
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Jul 11, 2024 | 
science.org | Jacob Landis |Meng-Ju Wu |Jason M. Tylianakis
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Jul 11, 2024 | 
science.org | Jacob Landis |Meng-Ju Wu |Valerie Thompson
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Jul 11, 2024 | 
science.org | Jacob Landis |Meng-Ju Wu |Nicola Lewis |Martin Beer
The relentless march of a highly pathogenic avian influenza virus (HPAIV) strain, known as H5N1, to become an unprecedented panzootic continues unchecked. The leap of H5N1 clade 2.3.4.4b from Eurasia and Africa to North America in 2021 and its further spread to South America and the Antarctic have exposed new avian and mammalian populations to the virus and led to outbreaks on an unrivaled scale.
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Jul 11, 2024 | 
science.org | Jacob Landis |Meng-Ju Wu |Michael Funk |Ian S. Osborne
Structural Biology Viewing synaptic vesicles up closeMichael A. FunkMolecular structure of V-ATPase embedded in the native synaptic vesicle membraneOpen in viewerChemical communication between neurons involves the rapid release of neurotransmitters into the synapse. Vesicular-type ATPase (V-ATPase) uses ATP to pump protons into synaptic vesicles, enabling neurotransmitter uptake from the cytosol before release. Coupland et al.
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Jul 11, 2024 | 
science.org | Jacob Landis |Meng-Ju Wu |Melissa McCartney |Caroline Ash
Science Education Searching for the right labMelissa McCartneySelecting a research lab is the cornerstone for many graduate school experiences; however, little is known about how graduate students find their research group. Verostek et al. systematically characterized the process by which 20 first- and second-year physics doctoral students searched for a research group.
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Jul 11, 2024 | 
science.org | Jacob Landis |Meng-Ju Wu |Valerie Thompson
Books et al. Science LivesTony Fauci reflects on a remarkable careerValerie Thompson [email protected] Info & AffiliationsGet full access to this articleView all available purchase options and get full access to this article. Books1On Call: A Doctor’s Journey in Public Service Anthony Fauci Viking, 2024. 480 pp.
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Jul 11, 2024 | science.org | Jacob Landis |Meng-Ju Wu |Valerie Thompson
Books et al. Science LivesTony Fauci reflects on a remarkable careerValerie Thompson [email protected] Info & AffiliationsGet full access to this articleView all available purchase options and get full access to this article. Books1On Call: A Doctor’s Journey in Public Service Anthony Fauci Viking, 2024. 480 pp.
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Jul 11, 2024 | 
science.org | Jacob Landis |Meng-Ju Wu |Jason M. Tylianakis
Amanda Black [email protected] and Jason M. TylianakisAuthors Info & AffiliationsScience11 Jul 2024Vol 385, Issue 6705pp. 152-153Get full access to this articleView all available purchase options and get full access to this article. References and Notes1N. Cartwright, E. Montuschi, Philosophy of Social Science: A New Introduction (Oxford Univ. Press, 2014). 2C. Wilkinson, D. C. Hikuroa, A. H. Macfarlane, M. W. Hughes, ESurf 8, 595 (2020). 3S. Tolbert, R. Hipkins, B. Cowie, P. Waiti, Int. J. Sci. Educ.
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Oct 4, 2023 | 
nature.com | Christina Baumgartner |Arvin Iracheta-Vellve |Kira E. Olander |Omar Ávila |Audrey J. Muscato |James C. Patti | +13 more
AbstractImmune checkpoint blockade is effective for some patients with cancer, but most are refractory to current immunotherapies and new approaches are needed to overcome resistance1,2. The protein tyrosine phosphatases PTPN2 and PTPN1 are central regulators of inflammation, and their genetic deletion in either tumour cells or immune cells promotes anti-tumour immunity3,4,5,6. However, phosphatases are challenging drug targets; in particular, the active site has been considered undruggable.
