Mengjie Chen

Jan 16, 2025 | cell.com | Anshul Kundaje |Katherine S. Pollard |Jian Ma |Xing Chang |Mengjie Chen |Remo Rohs

Jan 16, 2025 | cell.com | Anshul Kundaje |Katherine S. Pollard |Jian Ma |Xing Chang |Mengjie Chen |Remo Rohs

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Jun 2, 2024 | biorxiv.org | Mengjie Chen

AbstractThe concept of gene expression stability within a homeostatic cell is explored through the gene homeostasis Z-index, a measure that highlights genes under active regulation in response to internal and external stimuli. This index reveals distinct regulatory activities and patterns in different organs, such as enhanced synaptic transmission in pancreatic islets.

May 22, 2024 | physiciansweekly.com | Mengjie Chen

Variability in total cholesterol and triglyceride levels were linked to the development of type 2 diabetes complications. Clinicians should monitor lipid levels in addition to blood glucose in patients with type 2 diabetes, as changes in lipid levels are a pivotal risk factor for diabetes complications, according to findings published in Scientific Reports.

Apr 1, 2024 | nature.com | Mengjie Chen |Wenchao Li

AbstractProstate cancer (PCa) remains a significant cause of morbidity and mortality among men worldwide. A number of genes have been implicated in prostate tumorigenesis, but the mechanisms underlying their dysregulation are still incompletely understood. Evidence has established the competing endogenous RNA (ceRNA) theory as a novel regulatory mechanism for post-transcriptional alterations. Yet, a comprehensive characterization of ceRNA network in PCa lacks.