Mengke Fang

Oct 28, 2024 | nature.com | Yang Liu |Xue Xia |Linlin Fan |Mengke Fang |Yan Zou |Meng Zheng | +3 more

AbstractStrategies that selectively bind proteins of interest and target them to the intracellular protein recycling machinery for targeted protein degradation have recently emerged as powerful tools for undruggable targets in biomedical research and the pharmaceutical industry. However, targeting any new protein of interest with current degradation tools requires a laborious case-by-case design for different diseases and cell types, especially for extracellular targets.