Meredith Spradlin

Oct 25, 2024 | digitalcommons.library.tmc.edu | Sara Corvigno |Sunil P. Badal |Meredith Spradlin |Michael Keating

To view the content in your browser, please download Adobe Reader or, alternately, you may Download the file to your hard drive. NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.

Aug 15, 2024 | digitalcommons.library.tmc.edu | Deanna M. Glassman |Mark Kim |Sunil P. Badal |Meredith Spradlin

Despite modest clinical improvement with anti-vascular endothelial growth factor antibody (AVA) therapy in ovarian cancer, adaptive resistance is ubiquitous and additional options are limited. A dependence on glutamine metabolism, via the enzyme glutaminase (GLS), is a known mechanism of adaptive resistance and we aimed to investigate the utility of a GLS inhibitor (GLSi).