Methodios Ximerakis

2 months ago | nature.com | Methodios Ximerakis |Richard M. Giadone |Samara Santiago |Kavya Shah |Aviv Regev |Joshua Levin

Correction to: Nature Aging https://doi.org/10.1038/s43587-023-00373-6, published online 9 March 2023. Following publication, the authors were alerted to a potential duplication in two of the micrographs shown in the paper. After a detailed review, it appears that two probes (Hspa1a and Pecam1) in an RNA in situ hybridization experiment were unintentionally swapped in the representative images shown in Figs. 5c and 8b of the published manuscript.

Mar 9, 2023 | nature.com | Methodios Ximerakis |Richard M. Giadone |Kavya Shah |Aviv Regev |Joshua Levin |Samara Santiago

AbstractAging is a complex process involving transcriptomic changes associated with deterioration across multiple tissues and organs, including the brain. Recent studies using heterochronic parabiosis have shown that various aspects of aging-associated decline are modifiable or even reversible. To better understand how this occurs, we performed single-cell transcriptomic profiling of young and old mouse brains after parabiosis.