Michael A. Geeves

Dec 2, 2024 | cell.com | Matthew Carter Childers |Michael A. Geeves |Michael Regnier

Get full text accessLog in, subscribe or purchase for full access. References1. Sweeney, H.L. ∙ Hammers, D.W.Muscle ContractionCsh. Perspect. Biol. 2018; 10, a0232002. Sweeney, H.L. ∙ Houdusse, A. Structural and Functional Insights into the Myosin Motor MechanismAnnu. Rev. Biophys. 2010; 39:539-5573. Spudich, J.A.The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathyBiochem. Soc. Trans. 2015; 43:64-724. Brown, J.H. ∙ Kumar, V.S.S. ...

Jun 9, 2024 | biorxiv.org | Matthew Carter Childers |Michael A. Geeves |Michael Regnier

AbstractThe contraction of striated muscle is driven by cycling myosin motor proteins embedded within the thick filaments of sarcomeres. In addition to cross-bridge cycling with actin, these myosin proteins can enter an inactive, sequestered state in which the globular S1 heads rest along the thick filament surface and are unable to perform motor activities.