Michael Gray

Dec 7, 2024 | biorxiv.org | Julia Meredith |Michael Gray

AbstractOxidative stress is one of the major methods of microbial population control and pathogen clearing by the mammalian immune system. The methods by which bacteria are able to escape damage by host-derived oxidants such as hydrogen peroxide (H2O2) and hypochlorous acid (HOCl) have been relatively well described, while other oxidants’ effect on bacteria and their genetic responses are not as well understood. Hypothiocyanite/hypothiocyanous acid (-OSCN/HOSCN) is one such antimicrobial oxidant.

Jun 4, 2024 | hkclubbing.com | Baan Thai |Tazmania Ballroom |Red Sugar |Michael Gray

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Apr 21, 2024 | mja.com.au | Michael Gray |Diane Fatkin |Jodie Ingles |Elizabeth Robertson

Med J Aust || doi: 10.5694/mja2.52278 Published online: 22 April 2024 Cardiovascular disease (CVD) is the leading cause of morbidity and mortality globally and is responsible for an estimated 32% of deaths.1 An effort over many decades targeting modifiable risk factors has resulted in significant improvements in mortality and age‐adjusted prevalence.

Mar 8, 2024 | biorxiv.org | Michael Gray

AbstractThe innate immune system employs a variety of antimicrobial oxidants to control and kill host-associated bacteria. Hypothiocyanite/hypothiocyanous acid (-OSCN/HOSCN) is one such antimicrobial oxidant that is synthesized by lactoperoxidase, myeloperoxidase, and eosinophil peroxidase at sites throughout the human body. HOSCN has potent antibacterial activity while being largely non-toxic towards human cells.