Michael He

Aug 8, 2024 | nature.com | Michael He |Ting Liu |Guangrong Zheng |Ryder Whittaker Hawkins

AbstractDespite selective HDAC3 inhibition showing promise in a subset of lymphomas with CREBBP mutations, wild-type tumors generally exhibit resistance. Here, using unbiased genome-wide CRISPR screening, we identify GNAS knockout (KO) as a sensitizer of resistant lymphoma cells to HDAC3 inhibition.

Aug 6, 2024 | nature.com | Ting Liu |Michael He |Maja Ludvigsen |Maher Gandhi |Christian Steidl |Jan Delabie | +2 more

AbstractFollicular lymphoma (FL) exhibits considerable variability in biological features and clinical trajectories across patients. To dissect the diversity of FL, we utilized a Bernoulli mixture model to identify genetic subtypes in 713 pre-treatment tumor tissue samples. Our analysis revealed the existence of five subtypes with unique genetic profiles that correlated with clinicopathological characteristics.

May 23, 2023 | treasurytoday.com | Michael He

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