Michael Holmes

Jan 15, 2025 | biorxiv.org | Vishakha Dey |Michael Holmes |Sandeep Srivastava |Emma Wilson

AbstractToxoplasma gondii is a protozoan parasite that causes persistent infection in warm-blooded vertebrates by undergoing differentiation from a replicative stage (tachyzoites) to a latent encysted stage (bradyzoites). Stage differentiation is critical for transmission and pathogenesis and relies on gene regulation driven by a network of transcription and epigenetic factors.

Jun 14, 2024 | globalresearch.ca | Michael Holmes |Matthew Ehret-Kump

All Global Research articles can be read in 51 languages by activating the Translate Website button below the author’s name (only available in desktop version). To receive Global Research’s Daily Newsletter (selected articles), click here. Click the share button above to email/forward this article to your friends and colleagues. Follow us on Instagram and Twitter and subscribe to our Telegram Channel. Feel free to repost and share widely Global Research articles. Give Truth a Chance.

Mar 2, 2023 | thelancet.com | Madeleine Smith |Caroline J Bull |Michael Holmes |George Smith

SummaryBackgroundType 2 diabetes (T2D) and coronary artery disease (CAD) both have known genetic determinants, but the mechanisms through which their associated genetic variants lead to disease onset remain poorly understood. MethodsWe used large-scale metabolomics data in a two-sample reverse Mendelian randomization (MR) framework to estimate effects of genetic liability to T2D and CAD on 249 circulating metabolites in the UK Biobank (N = 118,466).