Michael Malloy

Washington

Managing Editor and Member Content at Actuarial Update

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Lung megakaryocytes are long-lived, arise from Flt3-negative bone marrow cells, and contribute to platelet recovery in thrombocytopenia

Apr 14, 2024 | biorxiv.org | Kathleen McGrath |Michael Malloy |Chen Li |Alison Livada

AbstractWe previously characterized lung megakaryocytes (Mks) as largely extravascular cells with an immune modulatory phenotype (Pariser et al., 2021). Because bone marrow (BM) Mks are relatively short lived, it is assumed that extravascular lung Mks are constantly seeded from the BM, but there are no experimental data to validate this concept.

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