Michael Zietz

Jun 13, 2024 | biorxiv.org | Michael Zietz |Kathleen Brown |Undina Gisladottir |Nicholas P. Tatonetti

AbstractComplex diseases are among the central challenges facing the world, and genetics underlie a large fraction of the risk. Observational data, such as electronic health records (EHR), offer numerous advantages in the study of complex disease genetics.

Jan 8, 2024 | nature.com | Kathleen Brown |Michael Zietz |Undina Gisladottir

AbstractSARS-CoV-2 has infected over 340 million people, prompting therapeutic research. While genetic studies can highlight potential drug targets, understanding the heritability of SARS-CoV-2 susceptibility and COVID-19 severity can contextualize their results. To date, loci from meta-analyses explain 1.2% and 5.8% of variation in susceptibility and severity respectively.

Nov 21, 2023 | biorxiv.org | Michael Zietz |Kathleen Brown |Nicholas P. Tatonetti |Undina Gisladottir

AbstractUnderstanding the genetic basis of complex disease is a critical research goal due to the immense, worldwide burden of these diseases. Pan-biobank genome-wide association studies (GWAS) provide a powerful resource in complex disease genetics, generating shareable summary statistics on thousands of phenotypes.