Michel G. Khouri

May 12, 2024 | jamanetwork.com | Senthil Selvaraj |Brian Claggett |Robert J. Mentz |Michel G. Khouri

Key PointsQuestion  What is the natural history and cardiovascular burden of the V142I variant of the transthyretin (TTR) gene among US Black carriers across mid to late life? Findings  Across 4 cohort studies, carriers (754/23 338) faced a substantially increased risk for heart failure (by age 63 years) and death (by age 72 years), similarly in men and women, which was estimated to contribute to approximately 1 million years of life lost among US Black individuals aged ≥50 years.