Michihito Kyo

4 weeks ago | jintensivecare.biomedcentral.com | Michihito Kyo |Modong Tan |Nobuaki Shime |Kengo Mekata |Nobuyuki Hirohashi

We conducted a meta-analysis using publicly available RNA-seq datasets to identify endotypes in sepsis. The analytic workflow is summarized in Figure S1. Briefly, we first performed a systematic search to identify eligible RNA-seq data of sepsis. To ensure robust analysis, we preprocessed the data by excluding low-quality samples (e.g., those with low mapping rates), filtering out low-expression genes, performing normalization, and correcting for batch effects across datasets.