Miguel Foronda

Aug 10, 2023 | nature.com | Miguel Foronda |Eric Gardner |Bianca Diaz |Kevin Holden |Scott Lowe

AbstractAlthough single-nucleotide variants (SNVs) make up the majority of cancer-associated genetic changes and have been comprehensively catalogued, little is known about their impact on tumor initiation and progression. To enable the functional interrogation of cancer-associated SNVs, we developed a mouse system for temporal and regulatable in vivo base editing.