Miguel Pacheco

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Articles

Multiprotein bridging factor 1 is required for robust activation of the integrated stress response on collided ribosomes

Nov 19, 2024 | cell.com | Kyusik Kim |Jeffrey Li |Miguel Pacheco |Victor Lasehinde |Timo I. Denk |Petr Tesina | +6 more

Keywordsintegrated stress responseribosometranslationribosome collisionsGcn2Gcn4Mbf1IntroductionDuring their lifetime, organisms face a multitude of stresses that can be detrimental for cellular homeostasis and that have driven the evolution of distinct stress-response pathways that allow organisms to survive and adapt through regulation of gene expression.
A Quote From Johann Goethe Redefined Freedom for Me

Oct 15, 2024 | medium.com | Miguel Pacheco

Just because you feel you can do whatever you like, it does not mean you are free. Miguel Pacheco·FollowPublished inKnow Thyself, Heal Thyself·4 min read·--Photo by Pablo Padilla on Unsplash“None are more hopelessly enslaved than those who falsely believe they are free.”Johann Wolfgang von GoetheFreedom has seriously been misrepresented in our society. I think it is destroying our mental health. Looking at the dictionary, freedom is defined as “the power to act, speak or think as one wants”.
I sat in meditation for 5 hours. Here is what happened

Oct 1, 2024 | medium.com | Miguel Pacheco

I felt as if I was connected to everythingMiguel Pacheco·FollowPublished inWrite A Catalyst·5 min read·--Photo by Prostock-studio on Envato. No, I’m not a Zen monk perpetually floating in bliss. But I’ve already lost count of the hours I’ve spent in meditation. In one of those times I slipped into a state so profound, so effortless, that when I finally returned, I realized five hours had passed. And during those hours, something truly magical and unique happened to me.
From Skeptic to Believer

Sep 29, 2024 | medium.com | Miguel Pacheco

My journey of discovering GodMiguel Pacheco·FollowPublished inKnow Thyself, Heal Thyself·5 min read·--Photo by Ian Stauffer on UnsplashI wasn’t always the guy who believed in anything spiritual. Back in 2010, I was a classic cynic. I just didn’t believe it, unless it couldn’t be seen or measured. God? A higher power? Come on, those were simply fairy tales, designed to keep the “people” subjugated. But here’s the spoiler: Now I know I was wrong.
How I started Overcoming Difficulties in Life

Sep 28, 2024 | medium.com | Miguel Pacheco

Finding hope in the depths of despairMiguel Pacheco·FollowPublished inKnow Thyself, Heal Thyself·6 min read·--Photo by Jeremy Perkins on UnsplashLife is abundant with challenges. Sometimes, they feel like growth opportunities, and we welcome them. But other times? They bring us to our knees. They leave us in despair. What can we do when life seems to punch us below the belt, refusing to play by the rules? And how do we stand back up when it feels like the circumstances changed without warning?
I Lived in a Spiritual Community For Five Years. This is What I’ve Learned

Sep 23, 2024 | medium.com | Miguel Pacheco

I Lived in a Spiritual Community For Five Years. This is What I’ve LearnedWhen I first stepped off the plane and took the bus toward a yoga spiritual community, my mind was filled with dreams of what it would be like. To be surrounded by like-minded spiritual seekers, meditators, and yoga practitioners… I believed life there would be perfect. Coming from a family where vociferous fighting was constant, I couldn’t wait to finally live with people who could get along.
How a Simple Ritual Became the Bedrock of My Spiritual Life

Sep 21, 2024 | medium.com | Miguel Pacheco

How a Simple Ritual Became the Bedrock of My Spiritual LifeGreat bliss can be found in creating a life of spiritual purpose. Unfortunately, peace and connection can often seem elusive, in this chaotic world. But there are ways…I used to believe that profound spiritual awareness could only be obtained via grand gestures or great wisdom. But I was wrong. True spirituality can sprout from the most mundane of actions.
The greatest secret to meditation none talks about

Sep 1, 2024 | miguel-paxeco.medium.com | Miguel Pacheco

The greatest secret to meditation none talks aboutSince childhood, my mind raced constantly and I struggled with concentration. Despite my love for studying and reading, I couldn’t do either for long. To make matters worse, my mind raced so much that I had to read the same sentence two, three, or even four times before grasping its meaning. In school, I would spend most of the classes daydreaming. Even during my college years, I would constantly just sit in the back mindlessly doodling.
People-Centered Living in Green and Blue Landscapes

Jun 1, 2024 | miguel-pacheco.medium.com | Miguel Pacheco

By Miguel Pacheco Microsoft's Copilot AI art based on this article's title Imagine you are now an all-powerful and mega-funded urbanist tasked with planning and constructing the greenest city ever. What items should be on your list? Far from street-level gaze, roofs barely register. Safe from a few observatories, penthouses, or sky bars, roofs are...
Geothermal, Tidal and Ocean Thermal Energy Conversion

May 9, 2024 | miguel-pacheco.medium.com | Miguel Pacheco