Miguel Santos

Sep 4, 2024 | ionline.sapo.pt | Miguel Santos

A educação, ao longo dos séculos, tem sido um pilar fundamental para o desenvolvimento das sociedades. No entanto, num mundo em constante evolução e transformação, é imperativo que as escolas também evoluam. A inovação nas escolas e colégios deve ir além da simples introdução de novas tecnologias, devendo partir de uma mudança de paradigma que valorize a partilha de conhecimentos, culturas e experiências, promovendo ambientes colaborativos e inclusivos.

May 18, 2024 | tandfonline.com | Miguel Santos

ABSTRACTIntroduction Amyotrophic lateral sclerosis (ALS) is a rapidly progressive motor neuron disorder with a fatal outcome 3–5 years after disease onset due to respiratory complications. Superoxide dismutase 1 (SOD1) mutations are found in about 2% of all patients. Tofersen is a novel oligonucleotide antisense drug specifically developed to treat SOD1-ALS patients. Areas covered Our review covers and discusses tofersen pharmacological properties and its phase I/II and III clinical trials results.

Jan 14, 2024 | onlinelibrary.wiley.com | Jose Castro |José Manuel Castro |Faculdade de Medicina |Instituto de Fisiología |Miguel Santos

DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the corresponding author upon reasonable request. ETHICS STATEMENT We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this report is consistent with those guidelines.