Miljan Stupar

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TcrXY is an acid-sensing two-component transcriptional regulator of Mycobacterium tuberculosis required for persistent infection - Nature Communications

Feb 22, 2024 | nature.com | Edward D. Kerr |Brian Forde |Benjamin Schulz |Miljan Stupar

AbstractThe ability of Mycobacterium tuberculosis (Mtb) to persist in the host complicates and prolongs tuberculosis (TB) patient chemotherapy. Here we demonstrate that a neglected two-component system (TCS) of Mtb, TcrXY, is an autoregulated acid-sensing TCS that controls a functionally diverse 70-gene regulon required for bacterial persistence.

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