Min Jung Kwun

Aug 13, 2024 | biorxiv.org | Min Jung Kwun |Alexandru Ion |Nicholas J Croucher |Katinka J Apagyi

AbstractMany integrative mobile genetic elements (MGEs) are sensitive to RecA-DNA filaments, suggesting their activation may enable them to evade deletion through homologous recombination (HR). This was studied using pneumococcal prophage. Most pneumococci contained prophage that inhibited transformation-mediated HR through chromosomal modification. These included a commonly-targeted attB that reduced transformation by modifying the small cytoplasmic RNA.