Ming Guo

Oct 7, 2024 | mdpi.com | Min Zhu |Ming Guo |Fei Wu |Sheng’ao Wang

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Aug 11, 2024 | nature.com | Yiwei Li |Ming Guo

AbstractLife, as a dense manifestation of soft matter, undergoes changes in water content, biomacromolecular concentrations, condensation and crowding due to volumetric compression. These molecular-level alterations in turn influence cell fate and function by modulating the kinetics and equilibria of biochemical reactions. Volumetric compression is a pervasive phenomenon in the human body, which manifests itself during development, limb movement, digestion, tumorigenesis and injury.

Jan 10, 2024 | nature.com | Ming Guo |Lin Chen |Ying Fu

AbstractNasopharyngeal carcinoma (NPC) is a malignant tumor that is highly prevalent in Southeast Asia, especially in South China. The pathogenesis of NPC is complex, and genetic alterations of tumor suppressors and proto-oncogenes play important roles in NPC carcinogenesis. p53 is unexpectedly highly expressed in NPC and possesses an uncommon mutation of R280T, which is different from a high frequency of hotspot mutations or low expression in other tumors.