Mingshu Sun

Feb 27, 2024 | acrjournals.onlinelibrary.wiley.com | Han Qi |Gout Qingdao |Mingshu Sun |Robert Terkeltaub

Objective Hyperuricemia can be stratified into four subtypes according to renal uric acid handling. The aim of this study was to comprehensively describe the biologic characteristics (including genetic background) of clinically defined hyperuricemia subtypes in two large geographically independent gout cohorts. Methods Hyperuricemia subtype was defined as renal uric acid overload (ROL), renal uric acid underexcretion (RUE), combined, or renal normal.

Dec 22, 2023 | acrjournals.onlinelibrary.wiley.com | Xiaomei Xue |Mingshu Sun |Nicola Dalbeth |Yuwei He

Objective There is an unmet need for simpler urate-lowering therapy (ULT) regimens that achieve the serum urate target and improve the overall quality of gout care. We report a comparative effectiveness trial of febuxostat monotherapy versus benzbromarone add-on to low-dose febuxostat in gout specifically with combined renal urate underexcretion and overload.