Minh-Tu Pham

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Endosomal egress and intercellular transmission of hepatic ApoE-containing lipoproteins and its exploitation by the hepatitis C virus

Jul 28, 2023 | journals.plos.org | Ji-Young Lee |Christian Ritter |Roman Thielemann |Minh-Tu Pham |PLOS Pathogens

Association and transmission of ApoE-positive lipoproteins with extracellular vesicles containing HCV NS5A and RNAApoE associates with NS5A in regions of endosomes containing HCV-produced intraluminal double or multi-membrane vesicles (Figs 6 and 7). Moreover, HCV suppresses the fusion of late endosomes with lysosomes [71]. Therefore, we hypothesized that secreted ApoE-LPs might associate with HCV-produced EVs containing NS5A and viral HCV RNA.

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