Mireia Sidera Portela

Jun 27, 2024 | digitalcommons.library.tmc.edu | Laura Cunningham |Stephen Fletcher |Mireia Sidera |Mireia Sidera Portela

Csp2–Csp2 Suzuki–Miyaura couplings (SMCs) are ubiquitous in the synthesis of small molecules, but analogous Csp2–Csp3 bond-forming SMCs are rare, especially asymmetric variants. Recently, we developed a series of Rh-catalyzed couplings between racemic sp3-hybridized allyl chlorides and heteroaryl boronic acids. Here, we demonstrate that these catalytic asymmetric reactions can be scaled-up to give over 100 g of a product.