Mitch Fahning

Aug 15, 2024 | biorxiv.org | Hannah A DeBerg |Mitch Fahning |James D Schlenker |William Schmitt

AbstractT cells and structural cells coordinate appropriate inflammatory responses and restoration of barrier integrity following insult. Dysfunctional T cell activity precipitates tissue pathology that occurs alongside disease-associated alterations of structural cell subsets, but the mechanisms by which T cells promote these changes remain unclear.

Jul 31, 2024 | biorxiv.org | Hannah A DeBerg |Mitch Fahning |William Schmitt |James D Schlenker

AbstractT cells coordinate with structural cells in the skin to promote appropriate inflammatory responses and subsequent restoration of barrier integrity following insult. Gene expression studies cataloging human skin have defined transcriptionally distinct structural cell populations in healthy tissue and identified inflammatory disease-associated changes in epithelial keratinocytes and dermal fibroblasts.