Mitsuko Watabe-Uchida

Jan 25, 2024 | cell.com | Ryunosuke Amo |Naoshige Uchida |Mitsuko Watabe-Uchida

Highlights • Activity of glutamate inputs to dopamine neurons is measured with a glutamate sensor • Glutamate inputs to dopamine neurons convey TD error • Aversive stimuli activate glutamate inputs but inhibit dopamine neurons • Opioids diminish dopamine inhibition at aversion but spare glutamate input excitation Summary Midbrain dopamine neurons are thought to signal reward prediction errors (RPEs), but the mechanisms underlying RPE computation, particularly the contributions of different...

Nov 10, 2023 | biorxiv.org | Ryunosuke Amo |Naoshige Uchida |Mitsuko Watabe-Uchida

AbstractMidbrain dopamine neurons are thought to signal reward prediction errors (RPEs) but the mechanisms underlying RPE computation, particularly contributions of different neurotransmitters, remain poorly understood. Here we used a genetically-encoded glutamate sensor to examine the pattern of glutamate inputs to dopamine neurons.