Mohammad Adnan Siddiqui

Oct 22, 2024 | biorxiv.org | Philipp N Ostermann |Youjun Wu |Scott Bowler |Mohammad Adnan Siddiqui

AbstractNeurocognitive impairment is a prevalent and important co-morbidity in virologically suppressed people living with HIV (PLWH), yet the underlying mechanisms remain elusive and treatments lacking. Here, we explored for the first time, use of participant-derived directly induced neurons (iNs) to model neuronal biology and injury in PLWH. iNs retain age- and disease-related features of the donors, providing unique opportunities to reveal novel aspects of neurological disorders.