Mrinmoy Sanyal

Jan 14, 2024 | nature.com | Duo Xu |Mrinmoy Sanyal

AbstractA major challenge in creating universal influenza vaccines is to focus immune responses away from the immunodominant, variable head region of hemagglutinin (HA-head) and toward the evolutionarily conserved stem region (HA-stem). Here we introduce an approach to control antigen orientation via site-specific insertion of aspartate residues that facilitates antigen binding to alum.

Oct 17, 2023 | biorxiv.org | Duo Xu |Abigail Powell |Mrinmoy Sanyal |Ashley Utz

AbstractEbola virus causes hemorrhagic fever in humans and poses a significant threat to global public health. Although two viral vector vaccines have been approved to prevent Ebola virus disease, they are distributed in the limited ring vaccination setting and only indicated for prevention of infection from orthoebolavirus zairense (EBOV) - one of three orthoebolavirus species that have caused previous outbreaks.