Nadia Arang

May 16, 2024 | biorxiv.org | Ling Wei |Umaru Barrie |Gina M Aloisio |Nadia Arang

AbstractThe Leishmania life cycle alternates between promastigotes, found in the sandfly, and amastigotes, found in mammals. When an infected sandfly bites a host, promastigotes are engulfed by phagocytes (i.e., neutrophils, dendritic cells, and macrophages) to establish infection. When these phagocytes die or break down, amastigotes must be re-internalized to survive within the acidic phagolysosome and establish disease.