Naganari Ohkura

May 25, 2023 | onlinelibrary.wiley.com | Kazunori Yokoi |Yoshiaki Yasumizu |Naganari Ohkura |Koei Shinzawa

Abstract Vitiligo is a common depigmentation disorder characterized by the selective loss of melanocytes. In our daily clinic experience, we noticed that the skin tightness of hypopigmented lesions would be more evident in comparison to that of uninvolved perilesional skin in vitiligo patients. Therefore, we hypothesized that collagen homeostasis might be maintained in vitiligo lesions, irrespective of the substantial excessive oxidative stress that occurs in association with the disease.