Natalie Kingston

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KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage - Nature Genetics

3 weeks ago | nature.com | Zheqi Li |Xintao Qiu |Marco Seehawer |Maeve McFadden |Eva Papachristou |Natalie Kingston | +17 more

AbstractBasal breast cancer is a subtype with a poor prognosis in need of more effective therapeutic approaches. Here we describe a unique role for the KDM4C histone lysine demethylase in KDM4C-amplified basal breast cancers, where KDM4C inhibition reshapes chromatin and transcriptomic landscapes without substantial alterations of its canonical substrates, trimethylated histone H3 lysine 9 (H3K9me3) and lysine 36 (H3K36me3).

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