Natalie Paredes

Sep 24, 2024 | biorxiv.org | Jacqueline Giovanniello |Natalie Paredes |Anna Wiener |Kathia Ramírez-Armenta

AbstractChronic stress can change how we learn and, thus, how we make decisions. Here we investigated the neuronal circuit mechanisms that enable this. Using a multifaceted systems neuroscience approach in male and female mice, we reveal a dual pathway, amygdala-striatal neuronal circuit architecture by which a recent history of chronic stress disrupts the action-outcome learning underlying adaptive agency and promotes the formation of inflexible habits.

Sep 24, 2024 | biorxiv.org | Jacqueline Giovanniello |Natalie Paredes |Anna Wiener |Kathia Ramírez-Armenta

AbstractChronic stress can change how we learn and, thus, how we make decisions. Here we investigated the neuronal circuit mechanisms that enable this. Using a multifaceted systems neuroscience approach in male and female mice, we reveal a dual pathway, amygdala-striatal neuronal circuit architecture by which a recent history of chronic stress disrupts the action-outcome learning underlying adaptive agency and promotes the formation of inflexible habits.

Oct 3, 2023 | biorxiv.org | Jacqueline Giovanniello |Anna Wiener |Natalie Paredes |Kathia Ramírez-Armenta

AbstractChronic stress can change how we learn and, thus, how we make decisions by promoting the formation of inflexible, potentially maladaptive, habits. Here we investigated the neuronal circuit mechanisms that enable this. Using a multifaceted approach in male and female mice, we reveal a dual pathway, amygdala-striatal, neuronal circuit architecture by which a recent history of chronic stress shapes learning to disrupt flexible goal-directed behavior in favor of inflexible habits.

Oct 3, 2023 | biorxiv.org | Jacqueline Giovanniello |Anna Wiener |Natalie Paredes |Kathia Ramírez-Armenta

AbstractChronic stress can change how we learn and, thus, how we make decisions by promoting the formation of inflexible, potentially maladaptive, habits. Here we investigated the neuronal circuit mechanisms that enable this. Using a multifaceted approach in male and female mice, we reveal a dual pathway, amygdala-striatal, neuronal circuit architecture by which a recent history of chronic stress shapes learning to disrupt flexible goal-directed behavior in favor of inflexible habits.