Nataly P. Podolnikova

May 9, 2024 | cell.com | Hoa Nguyen |Hoa Nguyễn |Nataly P. Podolnikova |Tatiana P. Ugarova |Xu Wang

Coxon A. Rieu P. Barkalow F.J. Askari S. Sharpe A.H. Von Andrian U.H. Arnaout M.A. Mayadas T.N. A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity. 1996; 5: 653-666The α subunit cytoplasmic domain regulates the assembly and adhesiveness of integrin lymphocyte function-associated antigen-1. J. Immunol.

Feb 2, 2024 | biorxiv.org | Hoa Nguyen |Hoa Nguyễn |Nataly P. Podolnikova |Xu Wang

AbstractThe integrin Mac-1 (aMb2, CD11b/CD18, CR3) is an important adhesion receptor expressed on macrophages and neutrophils. Mac-1 is also the most promiscuous member of the integrin family that binds a diverse set of ligands through its aMI-domain. However, the binding mechanism of most ligands is not clear. We have determined the interaction of aMI-domain with the cytokine pleiotrophin (PTN), a cationic protein known to bind aMI-domain and induce Mac-1-mediated cell adhesion and migration.