Nathan C. Gianneschi

Dec 5, 2024 | nature.com | Ummiye V. Onay |Dan Xu |Dauren Biyashev |Spencer T. Evans |Michael Demczuk |Nathan C. Gianneschi | +2 more

AbstractCutaneous exposure to the DNA alkylating class of chemotherapeutic agents including nitrogen mustard (NM) leads to both skin injury and systemic inflammation. Circulating myeloid subsets recruited to the skin act to further exacerbate local tissue damage while interfering with the wound healing process.

Nov 2, 2023 | nature.com | Zofia E. Siwicka |Dan Xu |Madison K. Ernst |Spencer T. Evans |Cuong Nguyen |cường nguyễn | +10 more

AbstractIn acute skin injury, healing is impaired by the excessive release of reactive oxygen species (ROS). Melanin, an efficient scavenger of radical species in the skin, performs a key role in ROS scavenging in response to UV radiation and is upregulated in response to toxic insult.